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Tesamorelin 2mg 5mg 10mg 20mg

5.8 USD ($)/Piece

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Product Details:

Grade Research Grade
CAS No 218949-48-5
EINECS No 603-809-2
Poisonous NO
Purity 99.0%
Appearance White powder
Product Type Peptides
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Product Description

Tesamorelin 2mg 5mg 10mg 20mg Price And Quantity

Price 5.8 USD ($)/Piece
Minimum Order Quantity 10 Piece

Tesamorelin 2mg 5mg 10mg 20mg Product Specifications

Purity 99.0%
Molecular Weight 5135.86 Milligram (mg)
Taste Other
Properties Tesamorelin is a synthetic growth hormone-releasing hormone analogue primarily used to reduce visceral fat accumulation (lipodystrophy) in HIV-infected individuals. Its core characteristics can be summarized as follows: 1) Pharmacological Properties: Mechanism of Action: It is a growth hormone-releasing factor (GRF) analogue that binds to and activates GRF receptors in the pituitary gland, stimulating the pituitary to secrete endogenous growth hormone (GH) in a pulsatile manner. Subsequently, growth hormone stimulates the liver to produce insulin-like growth factor 1 (IGF-1), which mediates most of the biological effects, including reducing visceral fat and regulating metabolism. Hepatic Effects: In clinical trials, tesamorelin did not cause elevated serum transaminases or significant liver damage; on the contrary, it was even associated with lowering existing ALT levels, potentially improving non-alcoholic fatty liver disease. 2) Pharmacokinetic Properties: Absorption and Bioavailability: Administered subcutaneously, the amount absorbed into systemic circulation is very limited, with an absolute bioavailability of less than 4%. Its pharmacokinetic characteristics are similar in HIV-infected individuals and healthy subjects, and are not significantly affected by factors such as age, body size, or race. Distribution and elimination: It has a large volume of distribution, averaging 200 liters; the elimination half-life is very short, approximately 8-26 minutes in healthy subjects and approximately 38 minutes in HIV-infected individuals. Metabolism and excretion: There are currently no formal human metabolic studies. 3) Clinical Characteristics: Primary indication: For reducing excess abdominal fat in patients with HIV-related lipodystrophy. It is important to emphasize that this is not a general medication for weight loss. Efficacy: Clinical studies have shown that daily subcutaneous injection of 2 mg for 26 weeks significantly reduces visceral adipose tissue (VAT) (average reduction of approximately 14-18%), with no adverse effects on subcutaneous fat in the extremities. It also lowers triglyceride levels. Administration: Once daily, subcutaneous injection. Dosage varies depending on the drug strength. For example, the recommended dose for the 1 mg/vial strength is 2 mg daily; the recommended dose for the 2 mg/vial strength (Egrifta SV) is 1.4 mg daily. 4) Safety Characteristics: Common Side Effects: Primarily include injection site reactions (such as redness, swelling, pain, and itching), arthralgia, muscle pain, and limb pain. Side Effects to Watch Out For: May cause elevated blood sugar (increased risk of glucose intolerance or type 2 diabetes), therefore, caution should be exercised in diabetic patients. In addition, fluid retention (manifested as arthralgia, carpal tunnel syndrome), allergic reactions (such as rash, shortness of breath), and antibody production may occur (occurring in approximately 50% of patients, but usually does not affect efficacy). Contraindications: Contraindicated in patients with hypersensitivity to any of the drug components, those with an active or previous history of malignancy, and patients with pituitary-related diseases (such as pituitary tumors). Contraindicated in pregnant women as it may harm the fetus. Drug Interactions: Concomitant use with corticosteroids (such as prednisone) may reduce the efficacy of the latter. No clinically significant interactions were observed when used in combination with simvastatin or ritonavir. It has minimal effect on the hepatic CYP3A enzyme system. 5) Chemical Properties: Chemical Nature: It is a polypeptide composed of 44 amino acids and is a synthetic analog of human natural growth hormone-releasing hormone (GHRH). Its chemical structure is C221-H366-N72-O67-S. Structural Modification: The N-terminus of its molecule has been modified (by adding a trans-3-hexenoyl group) to increase its stability and prolong its duration of action. Appearance: Usually a sterile, preservative-free lyophilized powder, which must be dissolved in the matching diluent before use.
Appearance White powder
Application Pharmaceutical
Product Type Peptides
Usage The primary use of Tesamorelin is to treat lipid dystrophism in HIV-infected individuals, specifically by reducing excess visceral fat around the liver. Main Uses and Efficacy: This drug works by mimicking the body natural growth hormone-releasing hormone, stimulating the pituitary gland to secrete growth hormone, thereby specifically regulating lipid metabolism. Multiple clinical studies have confirmed its effectiveness in the following areas: 1) Reducing Visceral Fat: Significantly reduces abdominal visceral fat accumulation (average reduction of approximately 14%-18%) and shrinks waist circumference. 2) Improving Liver Fat: Significantly reduces liver fat content, particularly beneficial for patients with HIV and metabolic-related fatty liver disease. 3) Optimizing Body Composition: While reducing trunk fat, it increases lean body mass (muscle mass) with minimal impact on subcutaneous fat.
Molecular Formula C221H366N72O67S
Ingredients Tesamorelin
HS Code 2937190099
Solubility Soluble in water
Physical Form Powder
Storage Freezer
Grade Research Grade
Shape other
CAS No 218949-48-5
Shelf Life 18 Months
Smell Other
EINECS No 603-809-2
Poisonous NO

Tesamorelin 2mg 5mg 10mg 20mg Trade Information

FOB Port Shenzhen
Payment Terms Telegraphic Transfer (T/T), Western Union
Supply Ability 5000 Piece Per Week
Delivery Time 5 Days
Sample Available Yes
Sample Policy If order is confirmed we will reimburse the sample cost
Packaging Details 10 Vials per Kit
Main Export Market(s) Asia, Australia, North America, South America, Western Europe
Main Domestic Market All India
Certifications GMP, ISO

Product Description

Tesamorelin is a synthetic growth hormone-releasing hormone analog and a GHRH agonist that stimulates the synthesis and release of endogenous growth hormone.

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