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China LL-37 5mg

Name: China LL-37 5mg
Brand: DALIAN HANDOM CHEMICALS CO.,LTD.
Price: 12.0 USD
Availability: InStock

12.0 USD ($)/Piece

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Product Details:

HS Code 2937190099
Product Type Peptides
Application Pharmaceutical
Properties 1. Physical Properties Appearance: The pure product is usually a white or off-white lyophilized solid powder. Net Charge: Under normal bodily conditions (pH 7.4), it carries a strong positive charge of +6. This makes it highly attractive to negatively charged bacterial surfaces. Isoelectric Point (pI): Approximately 10.61. It is a strongly basic polypeptide. 2. Spatial Structure Characteristics Chameleon-like Structure (Structural Plasticity): In pure water: It has no fixed shape and a loose structure, mainly in a random coil state. In the presence of salt or in contact with cell membranes: It rapidly twists into a very stable -helix structure. Perfect "Dual Nature" (Amphiphilicity): When it becomes an -helix, it exhibits dual affinity: The hydrophilic side: One side is lined with positively charged amino acids (lysine, arginine), which readily bind to water and bacterial surfaces. Hydrophobic surface: The other side is lined with water-averse amino acids (leucine, phenylalanine), which prefer to penetrate the lipid layer of bacterial cell membranes. 3. Environmental and Chemical Behavior Characteristics Concentration-dependent "aggregation" (oligomerization): At low concentrations (below 10 M), it prefers to work alone in solution (monomer form). At high concentrations or in saline environments, it aggregates in groups (forming dimers or tetramers). This aggregation behavior protects it from easy degradation by enzymes in the body. Salt sensitivity: The salt ion composition in solution alters its spatial shape. High concentrations of salt act as a shield, blocking its positive charge, thus slightly reducing its direct bactericidal rate, but not affecting its ability to call on immune cells. Protein resistance: Compared to other common peptides, LL-37 exhibits strong resistance to degradation by human proteases when bound to cell membranes, allowing it to survive longer in inflamed wounds.
Taste Other
Ingredients LL-37
Physical Form Powder
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China LL-37 5mg Price And Quantity

Price 12.0 USD ($)/Piece
Minimum Order Quantity 10 Piece

China LL-37 5mg Product Specifications

Solubility Soluble in water
Storage Freezer
Appearance White powder
Taste Other
CAS No 154947-66-7
Ingredients LL-37
HS Code 2937190099
Shelf Life 24 Months
Physical Form Powder
Usage 1. Broad-Spectrum Antimicrobial (Natural Antibiotic) LL-37 possesses a very strong direct bactericidal ability and is unlikely to induce bacterial resistance. Eliminating Bacteria: It has a strong killing effect on common bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Antiviral: It can destroy enveloped viruses (such as influenza virus and respiratory syncytial virus), preventing them from penetrating human cells. Inhibiting Fungi: It also has a significant inhibitory effect on fungi such as Candida albicans, which cause skin and mucous membrane infections. Disrupting Bacterial Biofilms: It can break down the "protective shell" (biofilm) formed by bacteria clump together, exposing and eliminating hidden bacteria. 2. Powerful Immunomodulatory Effects LL-37 is not just a "killer," but also a balancer of the immune system. Recruiting Immune Cells (Sentinel Function): When an infection occurs in the body, LL-37 releases signals to attract an "immune army" of neutrophils, macrophages, and other cells to the scene. Neutralizing Endotoxins: When bacteria die, they release toxic lipopolysaccharides (LPS/endotoxins), triggering severe systemic inflammatory responses (sepsis). LL-37 can directly bind to and neutralize these toxins, preventing uncontrolled inflammation. 3. Promotes Wound Healing and Tissue Regeneration LL-37 acts as an accelerator for wound repair when skin and mucous membranes are damaged. Promotes Skin Growth: It stimulates the division and migration of keratinocytes and epithelial cells, promoting rapid wound closure. Promotes Angiogenesis: It induces endothelial cells to form new microvessels, delivering oxygen and nutrients to damaged tissues, which is crucial for the healing of chronic ulcers such as diabetic foot. 4. Potential Anti-tumor and Metabolic Regulation Effects Bidirectional Tumor Regulation: In scientific research, LL-37 has exhibited complex regulatory effects on various cancers. It can inhibit the growth of certain tumors (such as colon cancer) by inducing apoptosis, making it a current research hotspot in cancer immunotherapy.
Purity 99%
Grade Research Grade
Product Type Peptides
Molecular Formula C205H340N60O53
Smell Other
Application Pharmaceutical
Properties 1. Physical Properties Appearance: The pure product is usually a white or off-white lyophilized solid powder. Net Charge: Under normal bodily conditions (pH 7.4), it carries a strong positive charge of +6. This makes it highly attractive to negatively charged bacterial surfaces. Isoelectric Point (pI): Approximately 10.61. It is a strongly basic polypeptide. 2. Spatial Structure Characteristics Chameleon-like Structure (Structural Plasticity): In pure water: It has no fixed shape and a loose structure, mainly in a random coil state. In the presence of salt or in contact with cell membranes: It rapidly twists into a very stable -helix structure. Perfect "Dual Nature" (Amphiphilicity): When it becomes an -helix, it exhibits dual affinity: The hydrophilic side: One side is lined with positively charged amino acids (lysine, arginine), which readily bind to water and bacterial surfaces. Hydrophobic surface: The other side is lined with water-averse amino acids (leucine, phenylalanine), which prefer to penetrate the lipid layer of bacterial cell membranes. 3. Environmental and Chemical Behavior Characteristics Concentration-dependent "aggregation" (oligomerization): At low concentrations (below 10 M), it prefers to work alone in solution (monomer form). At high concentrations or in saline environments, it aggregates in groups (forming dimers or tetramers). This aggregation behavior protects it from easy degradation by enzymes in the body. Salt sensitivity: The salt ion composition in solution alters its spatial shape. High concentrations of salt act as a shield, blocking its positive charge, thus slightly reducing its direct bactericidal rate, but not affecting its ability to call on immune cells. Protein resistance: Compared to other common peptides, LL-37 exhibits strong resistance to degradation by human proteases when bound to cell membranes, allowing it to survive longer in inflamed wounds.
Poisonous NO
Shape other
EINECS No N/A

China LL-37 5mg Trade Information

FOB Port Shenzhen
Payment Terms Telegraphic Transfer (T/T), Western Union
Supply Ability 10000 Piece Per Week
Delivery Time 3 Days
Sample Available No
Sample Policy If order is confirmed we will reimburse the sample cost
Packaging Details 10 vials/box
Main Export Market(s) Australia, Asia, Western Europe, North America
Certifications GMP, ISO

Product Description

LL-37 is a very important natural antimicrobial peptide in the human body. It is the only member of the human Cathelicidin antimicrobial peptide family and is composed of 37 amino acids. As a member of the human innate immune system, it acts like a "natural antibiotic" in the body, playing a central role in protecting the body from pathogens.

Structural Versatility and Unique Physical Properties

LL-37 demonstrates remarkable chameleon-like structural plasticity. In pure water, it remains flexible, but in the presence of salts or cell membranes, it forms a stable alpha-helix vital for its bioactivity. This amphiphilic nature enables effective interaction with both hydrophilic and hydrophobic environments, enhancing its antimicrobial potency and resilience against protease degradation.

Broad-Spectrum Antimicrobial and Antiviral Actions

As a natural antibiotic, LL-37 delivers potent bactericidal activity against pathogens such as Staphylococcus aureus and E. coli, as well as antiviral effects on influenza and RSV. It disrupts bacterial biofilms and displays antifungal properties, targeting Candida albicans. These properties make LL-37 a promising candidate for combating resistant infections in research settings.

Immunomodulation and Tissue Regeneration

Beyond pathogen elimination, LL-37 acts as an immunomodulator, recruiting immune cells to sites of infection and neutralizing bacterial endotoxins. It also boosts tissue repair by promoting skin cell proliferation and angiogenesis, essential for wound healing and chronic ulcer recovery-demonstrating multifunctional potential in pharmaceutical research.

FAQ's of China LL-37 5mg:

Q: What is the primary use of China LL-37 5mg in research?

A: China LL-37 5mg is primarily utilized in pharmaceutical and biomedical research for its broad-spectrum antimicrobial, antiviral, antifungal, immunomodulatory, tissue regeneration, and potential anti-tumor properties.

Q: How should LL-37 powder be stored to maintain its stability?

A: LL-37 should be kept in a freezer, ideally at -20C or lower, to protect its purity (99%) and ensure maximum shelf life of 24 months.

Q: What makes LL-37 effective against bacteria and viruses?

A: LL-37 features a strong positive charge and an amphiphilic alpha-helix structure, allowing it to bind and disrupt bacterial cell membranes, destroy enveloped viruses, and break down protective biofilms, while being resistant to enzymatic degradation.

Q: How soluble is LL-37, and what solvent should be used for application?

A: LL-37 is highly soluble in water. It can be easily dissolved in sterile water or buffer solutions suitable for research use.

Q: What benefits does LL-37 offer in wound healing research?

A: LL-37 promotes keratinocyte and epithelial cell migration, enhances angiogenesis, and accelerates tissue regeneration, making it valuable for studying new therapies in wound repair and chronic ulcer treatment.

Q: Is LL-37 safe to handle and is it considered poisonous?

A: LL-37 is classified as non-poisonous, making it safe for trained laboratory personnel to handle when standard laboratory safety protocols are followed.

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