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China LL-37 5mg
12.0 USD ($)/Piece
Product Details:
- Shape other
- Application Pharmaceutical
- Product Type Peptides
- Shelf Life 24 Months
- Usage 1. Broad-Spectrum Antimicrobial (Natural Antibiotic) LL-37 possesses a very strong direct bactericidal ability and is unlikely to induce bacterial resistance. Eliminating Bacteria: It has a strong killing effect on common bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Antiviral: It can destroy enveloped viruses (such as influenza virus and respiratory syncytial virus), preventing them from penetrating human cells. Inhibiting Fungi: It also has a significant inhibitory effect on fungi such as Candida albicans, which cause skin and mucous membrane infections. Disrupting Bacterial Biofilms: It can break down the "protective shell" (biofilm) formed by bacteria clump together, exposing and eliminating hidden bacteria. 2. Powerful Immunomodulatory Effects LL-37 is not just a "killer," but also a balancer of the immune system. Recruiting Immune Cells (Sentinel Function): When an infection occurs in the body, LL-37 releases signals to attract an "immune army" of neutrophils, macrophages, and other cells to the scene. Neutralizing Endotoxins: When bacteria die, they release toxic lipopolysaccharides (LPS/endotoxins), triggering severe systemic inflammatory responses (sepsis). LL-37 can directly bind to and neutralize these toxins, preventing uncontrolled inflammation. 3. Promotes Wound Healing and Tissue Regeneration LL-37 acts as an accelerator for wound repair when skin and mucous membranes are damaged. Promotes Skin Growth: It stimulates the division and migration of keratinocytes and epithelial cells, promoting rapid wound closure. Promotes Angiogenesis: It induces endothelial cells to form new microvessels, delivering oxygen and nutrients to damaged tissues, which is crucial for the healing of chronic ulcers such as diabetic foot. 4. Potential Anti-tumor and Metabolic Regulation Effects Bidirectional Tumor Regulation: In scientific research, LL-37 has exhibited complex regulatory effects on various cancers. It can inhibit the growth of certain tumors (such as colon cancer) by inducing apoptosis, making it a current research hotspot in cancer immunotherapy.
- Grade Research Grade
- Appearance White powder
- Click to View more
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China LL-37 5mg Price And Quantity
- 12.0 USD ($)/Piece
- 10 Piece
China LL-37 5mg Product Specifications
- NO
- Powder
- C205H340N60O53
- N/A
- 1. Physical Properties Appearance: The pure product is usually a white or off-white lyophilized solid powder. Net Charge: Under normal bodily conditions (pH 7.4), it carries a strong positive charge of +6. This makes it highly attractive to negatively charged bacterial surfaces. Isoelectric Point (pI): Approximately 10.61. It is a strongly basic polypeptide. 2. Spatial Structure Characteristics Chameleon-like Structure (Structural Plasticity): In pure water: It has no fixed shape and a loose structure, mainly in a random coil state. In the presence of salt or in contact with cell membranes: It rapidly twists into a very stable -helix structure. Perfect "Dual Nature" (Amphiphilicity): When it becomes an -helix, it exhibits dual affinity: The hydrophilic side: One side is lined with positively charged amino acids (lysine, arginine), which readily bind to water and bacterial surfaces. Hydrophobic surface: The other side is lined with water-averse amino acids (leucine, phenylalanine), which prefer to penetrate the lipid layer of bacterial cell membranes. 3. Environmental and Chemical Behavior Characteristics Concentration-dependent "aggregation" (oligomerization): At low concentrations (below 10 M), it prefers to work alone in solution (monomer form). At high concentrations or in saline environments, it aggregates in groups (forming dimers or tetramers). This aggregation behavior protects it from easy degradation by enzymes in the body. Salt sensitivity: The salt ion composition in solution alters its spatial shape. High concentrations of salt act as a shield, blocking its positive charge, thus slightly reducing its direct bactericidal rate, but not affecting its ability to call on immune cells. Protein resistance: Compared to other common peptides, LL-37 exhibits strong resistance to degradation by human proteases when bound to cell membranes, allowing it to survive longer in inflamed wounds.
- Research Grade
- Soluble in water
- LL-37
- White powder
- 99%
- 2937190099
- Freezer
- 24 Months
- Other
- 154947-66-7
- 1. Broad-Spectrum Antimicrobial (Natural Antibiotic) LL-37 possesses a very strong direct bactericidal ability and is unlikely to induce bacterial resistance. Eliminating Bacteria: It has a strong killing effect on common bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Antiviral: It can destroy enveloped viruses (such as influenza virus and respiratory syncytial virus), preventing them from penetrating human cells. Inhibiting Fungi: It also has a significant inhibitory effect on fungi such as Candida albicans, which cause skin and mucous membrane infections. Disrupting Bacterial Biofilms: It can break down the "protective shell" (biofilm) formed by bacteria clump together, exposing and eliminating hidden bacteria. 2. Powerful Immunomodulatory Effects LL-37 is not just a "killer," but also a balancer of the immune system. Recruiting Immune Cells (Sentinel Function): When an infection occurs in the body, LL-37 releases signals to attract an "immune army" of neutrophils, macrophages, and other cells to the scene. Neutralizing Endotoxins: When bacteria die, they release toxic lipopolysaccharides (LPS/endotoxins), triggering severe systemic inflammatory responses (sepsis). LL-37 can directly bind to and neutralize these toxins, preventing uncontrolled inflammation. 3. Promotes Wound Healing and Tissue Regeneration LL-37 acts as an accelerator for wound repair when skin and mucous membranes are damaged. Promotes Skin Growth: It stimulates the division and migration of keratinocytes and epithelial cells, promoting rapid wound closure. Promotes Angiogenesis: It induces endothelial cells to form new microvessels, delivering oxygen and nutrients to damaged tissues, which is crucial for the healing of chronic ulcers such as diabetic foot. 4. Potential Anti-tumor and Metabolic Regulation Effects Bidirectional Tumor Regulation: In scientific research, LL-37 has exhibited complex regulatory effects on various cancers. It can inhibit the growth of certain tumors (such as colon cancer) by inducing apoptosis, making it a current research hotspot in cancer immunotherapy.
- Other
- other
- Pharmaceutical
- Peptides
China LL-37 5mg Trade Information
- Shenzhen
- Telegraphic Transfer (T/T), Western Union
- 10000 Piece Per Week
- 3 Days
- Yes
- If order is confirmed we will reimburse the sample cost
- 10 vials/box
- Asia, Australia, North America, Western Europe
- GMP, ISO
Product Description
LL-37 is a very important natural antimicrobial peptide in the human body. It is the only member of the human Cathelicidin antimicrobial peptide family and is composed of 37 amino acids. As a member of the human innate immune system, it acts like a "natural antibiotic" in the body, playing a central role in protecting the body from pathogens.Tell us about your requirement
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DALIAN HANDOM CHEMICALS CO.,LTD.
RM702, Unit 1, Building 21, Liuhe Road, Ganjingzi Dist,Dalian - 116091, Liaoning, China
Phone :--+8615840669648
Send InquiryE-mail us : export@handom-chem.com
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