Cathelicidin LL-37 (Human)

Usage:1) New Drugs: Low expression of TLR2 and LL-37 and low level of serum LL-37 in children with atopic dermatitis (AD) suggest that AD has problems such as innate immunity and skin barrier function defects. Vitamin D may activate vitamin D receptors and promote LL-37 expression through the TLR2 pathway, thereby protecting AD. Perhaps in the future, LL-37-related drugs can be designed to assist vitamin D in combating atopic dermatitis. Neonatal sepsis is mainly caused by infection. With the emergence of drug-resistant bacteria, antibiotic selection has become increasingly difficult, so it is particularly important to improve one's own resistance. Studies have shown that vitamin D can increase the expression of the body's antimicrobial peptide LL-37, thereby improving the body's ability to defend against infection and providing strong protection for antibiotic treatment. This will provide ideas for designing drugs that replace antibiotics. 2) Animal Feed Additives: LL-37 has a broad antibacterial spectrum and high antibacterial activity, bacteria are not easy to develop drug resistance, it can also neutralize endotoxins and can be regarded as a new alternative to antibiotics. Therefore, choosing a suitable expression template to express LL-37 analogs will promote the production of animal feed additives with high antibacterial efficiency and high nutrition, making it have certain economic benefits. 3) Preservatives: LL-37 and CP1 are produced on a large scale through genetic engineering, they have strong antibacterial activity, small relative molecular mass, high antibacterial activity when heated at 121 for 30 minutes, good water solubility, safe and non-toxic, and not easy to develop drug resistance. Adding an appropriate amount of antimicrobial peptides to milk has a certain preservation effect on storage.
Properties:1) Antimicrobial: As an important member of the natural immune system, LL-37 has strong antimicrobial activity both in vivo and in vitro, including Gram-positive bacteria (such as Staphylococcus aureus, Streptococcus, etc.), Gram-negative bacteria (such as Salmonella, Escherichia coli, etc.), fungi and viruses. Moreover, LL-37 also has a certain selective killing effect on some fungi, viruses, tumor cells and protozoa. 2) Regulate the Release of Immune and Inflammatory Mediators: LL-37 can cause immune cell differentiation and chemotaxis, induce cell differentiation, cytokine release, neutralize endotoxins and anti-tumor, etc., and enhance the body's ability to resist harmful microorganisms. Advantages: Compared with traditional antibiotics, Antimicrobial Peptide LL-37 human can kill pathogens, is not easy to produce drug resistance, and is not easy to produce immune rejection reactions. It is an important effector molecule of the natural immune system.
Storage:Freezer
Product Type:Lyophilized Powder
CAS No:154947-66-7
EINECS No:211-519-9
Molecular Formula:C205H340N60O53
Supply Ability:5000 Per Week

Price: 8.6 USD ($)/Piece

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Thymosin Alpha 1 (Thymalfasin)

Supply Ability:5000 Per Week
Application:Pharmaceutical
Smell:Other
Physical Form:Powder
Appearance:White powder
Ingredients:Thymosin Alpha 1 (Thymalfasin)
Molecular Weight:3108.30 Grams (g)
Shelf Life:24 Months

Price: 2.75 USD ($)/Piece

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MOTS-c (Human)

Supply Ability:5000 Per Week
Properties:MOTS-C (Mitochondria-derived peptide MOTS-C) is a short peptide encoded by mitochondrial genes with multiple biological properties and functions. Biological Properties: MOTS-C is a 16-amino acid short peptide encoded by mitochondrial 12S rRNA, which has a cytoprotective effect. It activates the AMPK (adenosine activated protein kinase) pathway, increases the number of glucose transporters on the cell membrane surface, promotes cellular glucose uptake, and reduces lipid droplet deposition. In addition, MOTS-C also has anti-inflammatory and antioxidant properties, can inhibit the production of inflammatory mediators, reduce oxidative stress, and provide new strategies for the prevention and treatment of chronic diseases such as cardiovascular disease and diabetes. Biological Functions: 1) Metabolic regulation: MOTS-C regulates cell metabolism, promotes fatty acid oxidation, and maintains energy balance by activating AMPK. It can also reduce lipid droplet deposition, increase the activation of brown fat with faster metabolism, and reduce the accumulation of white fat with slower metabolism by inhibiting the synthesis of adipocyte-related genes. 2) Anti-inflammatory and antioxidant : MOTS-C exhibits strong anti-inflammatory and antioxidant properties, can inhibit the production of inflammatory mediators, reduce oxidative stress, and has a preventive and therapeutic effect on chronic diseases such as cardiovascular disease and diabetes. 3) Cytoprotection : MOTS-C has a cytoprotective effect, can maintain cell homeostasis under metabolic stress conditions, and help cells adapt to damaged homeostasis .
Usage:1) Treatment of Metabolic Diseases: For metabolic disorders such as obesity and diabetes, MOTS-c may become a new drug target to improve insulin resistance by simulating or enhancing its activity. 2) Anti-aging and Geriatric Disease Intervention: Its application in delaying aging, preventing and treating neurodegenerative diseases and cardiovascular diseases is being explored. 3) Antiviral Therapy: For viral infections such as HBV, MOTS-c's function of regulating mitochondrial dynamics provides a basis for the development of antiviral therapy.
Storage:Freezer
Product Type:Lyophilized Powder(Freeze-dried Powder)
CAS No:1627580-64-6
Molecular Formula:C101H152N28O22S2
Taste:Other

Price: 6.5 USD ($)/Piece

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Retatrutide 5mg/10mg/15mg/20mg/30mg

Supply Ability:500 Per Week
CAS No:2381089-83-2
Product Type:Peptide Preparations
Storage:Freezer
Usage:1) Obesity Treatment: In the Phase II clinical trial, patients in the highest dose group (12 mg) lost an average of 24.2% weight after 48 weeks, and some patients lost more than 30%. 2) Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD): Retatrutide can reduce liver fat content by 86%, and more than 85% of patients achieve regression of liver steatosis. 3) Type 2 Diabetes: Significantly reduce glycated hemoglobin (HbA1c) and improve blood sugar control. 4) Potential Cardiovascular Benefits: Animal studies have shown that it may indirectly protect cardiovascular health by improving blood pressure and heart function, but further clinical verification is needed.
Properties:1) Triple receptor agonism: Retatrutide is a GGG triple agonist that can act on three receptors simultaneously: glucagon-like peptide-1 receptor (GLP-1R), gastric inhibitory peptide receptor (GIPR) and glucagon receptor (GCGR). This triple mechanism of action makes it excellent in controlling appetite, delaying gastric emptying and increasing energy expenditure. 2) Significant weight loss effect: Clinical trials have shown that Retatrutide is effective in weight loss. At the highest dose, participants lost an average of 24.2% weight in 11 months, which is far superior to the 15-20% weight loss effect of other GLP-1 receptor agonists currently on the market (such as Semaglutide and Tirzepatide). 3) Metabolic regulation: Retatrutide can not only effectively reduce weight, but also improve metabolic indicators. For example, it can significantly reduce glycosylated hemoglobin (HbA1c) levels and has a positive effect on blood sugar control in patients with type 2 diabetes. In addition, it may also have a beneficial effect on cardiovascular health, although this area still needs further research. 4) Long-term effect and convenience: Retatrutide has been modified by fatty acid acylation and can bind to albumin in the blood, thereby extending its half-life. This means that patients only need to inject once a week, which is more convenient to use.
Taste:Other
Grade:Pharmaceutical Grade

Price: 100.0 USD ($)/Box

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Bremelanotide (PT-141)

Ingredients:Bremelanotide
Poisonous:NO
Shelf Life:24 Months
Molecular Weight:1025.16 Grams (g)
Smell:Other
Application:medicine
Appearance:White powder
Supply Ability:5000 Per Week

Price: 5.4 USD ($)/Piece

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TB500 (Thymosin B4 Acetate)

Purity:Not less than 99%
Color:White
Solubility:Soluble in water
EINECS No:1592732-453-0
Type:Immune Function Agents
Storage:Freezer
Usage:1) Sports Medicine: Athletes or fitness enthusiasts use it to accelerate the recovery of muscle strains and ligament tears. 2) Chronic Injuries: Auxiliary treatment of arthritis and tendinitis. 3) Skin Repair: Promote the healing of burns or surgical wounds (experimental stage).
Supply Ability:5000 Per Week