Semax 5mg 10mg 30mg

Product Details:

• Grade Research Grade
• Usage Semax possesses immunomodulatory, nootropic, and neuroprotective activities. Semax can be used in research on central nervous system diseases such as Alzheimer's disease and cerebral ischemia.
• Solubility Soluble in water
• Taste Other
• Physical Form Powder
• Density 1.391 0.06 Gram per cubic centimeter(g/cm3)
• Properties Semax is a synthetic neuroprotective peptide primarily used in stroke research and central nervous system function regulation. As an analog of the adrenocorticotropic hormone (ACTH) fragment, it crosses the blood-brain barrier through a unique mechanism, promoting nerve regeneration and repair. In experimental models, it has shown potential to improve cerebral blood flow and regulate neurotransmitter activity; however, its clinical application requires further validation. I. Structure and Bioactivity: Semax is a synthetic analog of the ACTH (4-10) fragment. Its chemical structure removes the hormonal activity while retaining its neuroregulatory function. Its derivative, Semax acetate (CAS 2828433-33-4), has become the primary form in research due to its enhanced stability and improved bioavailability. This modification allows it to rapidly cross the blood-brain barrier after intranasal administration, with a single dose lasting up to 24 hours, making it suitable for acute neurological injury scenarios. II. Mechanism of Action and Neuroprotective Effects: Semax exerts its effects through a dual pathway: Promoting the expression of neurotrophic factors: Upregulating the levels of BDNF and its receptor TrkB in the hippocampus, directly supporting neuronal survival and synaptic plasticity, and accelerating neural circuit reconstruction after injury; Regulating the neurotransmitter system: Activating the serotonin and dopamine pathways, improving mood and cognitive function. Experiments show that it can counteract cognitive impairment caused by chronic stress, while enhancing D-phenylpropanol-induced motor activity, suggesting that it has a bidirectional regulatory capacity on neural excitability.
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