IGF-1 LR3 0.1mg/1mg China

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Ph Level 6.5~7.5
Purity 99.00%
Molecular Formula C400H625N111O115S9
Appearance White powder
Grade Research Grade
Shape Irregular
Solubility IGF-1 LR3 has low solubility in standard purified water or certain neutral media; direct reconstitution often leads to aggregation or incomplete dissolution. Due to its amino acid sequence and structural characteristics, it is generally more soluble in weakly acidic solutions than in neutral or slightly alkaline conditions an environment that also better preserves its structural integrity and prevents degradation.
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IGF-1 LR3 0.1mg/1mg China Price And Quantity

Minimum Order Quantity 10 Piece
Price 4.0 USD ($)/Piece

IGF-1 LR3 0.1mg/1mg China Product Specifications

Product Type Peptides
Storage Freezer
Usage IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetically modified analog of human insulin-like growth factor-1 (IGF-1). It features an extension of 13 amino acids at the N-terminus and the substitution of glutamic acid with arginine at the third position. These modifications reduce its affinity for IGF-binding proteins (IGFBPs) in the body, thereby significantly extending its half-life and biological activity. Its primary applications and research areas include: 1. Laboratory and Biotechnological Applications Serum-free cell culture: Used as a key additive in *in vitro* cell culture to promote the growth of various cell types such as CHO cells, cell lines used for vaccine production, fibroblasts, and stem cells and to enhance the production of recombinant proteins. 2. Medical and Preclinical Research Tissue repair and wound healing: By activating the AKT signaling pathway, it promotes cell proliferation and inhibits apoptosis; it is being investigated for the repair of hard-to-heal wounds or diabetic foot ulcers. Metabolic and growth regulation: It is studied for its potential role in addressing insulin resistance, treating diabetes, managing myasthenia gravis, and intervening in cases of fetal growth restriction. 3. Sports and Fitness (Unofficial/Controversial Use) Muscle growth promotion: By increasing protein synthesis, enhancing the utilization of amino acids and glucose, and inducing muscle fiber hyperplasia (an increase in the number of muscle cells, rather than just an increase in cell size), it is used by some in the fitness and bodybuilding communities to build muscle and optimize body composition. Accelerated recovery: Used to alleviate muscle soreness and inflammation following high-intensity training, and to shorten the recovery period from fatigue.
Properties IGF-1 LR3 (Long R3 Insulin-like Growth Factor-I) is a genetically engineered, recombinant analogue of human insulin-like growth factor-1 (IGF-1). It is widely used in scientific research and cell culture, with the following core characteristics: 1. Molecular Structural Features Amino Acid Extension: An additional 13 amino acids are appended to the N-terminus of the native IGF-1 molecule (which consists of 70 amino acids and has a molecular weight of approximately 7.4 kDa). This results in a total of 83 amino acids and a molecular weight of approximately 9.1 9.2 kDa. Site Substitution: The glutamic acid (Glu/E) at position 3 is replaced by arginine (Arg/R), which is the origin of the designation "R3." Spatial Structure: It retains the tertiary structure of the native molecule, including its 6 cysteine residues and 3 disulfide bonds. 2. Key Biological Properties Extremely Low Affinity for Binding Proteins: In the bloodstream, the vast majority of native IGF-1 binds to IGF-binding proteins (IGFBPs), which effectively "sequester" it and render it inactive. In contrast, the structural modifications in IGF-1 LR3 prevent it from binding to these proteins, allowing it to remain in a highly active, free state within bodily fluids. Significantly Extended Half-life: While the half-life of native IGF-1 is typically less than 10 minutes, IGF-1 LR3 freed from the constraints of binding proteins exhibits a plasma half-life extended to approximately 20 30 hours. Enhanced Biological Activity: Because it remains in a free, highly active state and can frequently bind to its receptors, its in vitro biological activity is 2 to 3 times greater than that of native IGF-1 (with some studies suggesting an even higher potency). It also demonstrates a lower affinity for the insulin receptor. Signaling Pathway Transduction: It serves as a potent activator of the AKT signaling pathway, effectively stimulating cell growth, promoting cell proliferation, and inhibiting apoptosis. 3. Key Application Scenarios Serum-Free Cell Culture: Frequently used as a highly effective cell culture additive to promote the division, migration, and differentiation of various cell types, thereby enhancing the production efficiency of recombinant proteins and biological products. Scientific and Medical Research: Utilized to investigate mechanisms of tissue repair and cell proliferation, as well as to explore pharmacological properties in fields such as cardiovascular research.
CAS No 946870-92-4
Poisonous NO
HS Code 2937190099
Solubility IGF-1 LR3 has low solubility in standard purified water or certain neutral media; direct reconstitution often leads to aggregation or incomplete dissolution. Due to its amino acid sequence and structural characteristics, it is generally more soluble in weakly acidic solutions than in neutral or slightly alkaline conditions an environment that also better preserves its structural integrity and prevents degradation.
Smell Other
Grade Research Grade
Shape Irregular
Taste Odorless
EINECS No 1592732-453-0
Shelf Life 18 Months
Ingredients IGF-1 LR3
Molecular Formula C400H625N111O115S9
Physical Form Powder
Appearance White powder
Ph Level 6.5~7.5
Purity 99.00%
Application medicine

IGF-1 LR3 0.1mg/1mg China Trade Information

FOB Port Shenzhen or Guangzhou
Payment Terms Telegraphic Transfer (T/T), Western Union
Supply Ability 10000 Piece Per Week
Delivery Time 5 Days
Sample Available Yes
Sample Policy Free samples available with shipping and taxes paid by the buyer
Packaging Details 10 vials per box.
Main Export Market(s) Asia, Australia, North America, South America, Western Europe
Main Domestic Market All India
Certifications ISO9001, GMP

Product Description

IGF-1 LR3 (Long Arginine 3-Insulin-like Growth Factor-1) is a synthetic analog of human insulin-like growth factor-1 (IGF-1).

Key Characteristics & Structure

Chemical Modifications: It is an 83-amino-acid protein featuring two distinct alterations compared to natural IGF-1 (which has 70 amino acids):

An arginine replaces glutamic acid at position 3.

A 13-amino-acid extension is added to the N-terminus (MFPAMPLLSLFVN).

Extended Half-Life: These modifications significantly reduce its ability to bind to insulin-like growth factor-binding proteins (IGFBP). This increases its metabolic stability and extends its elimination half-life to roughly 2030 hours (compared to just a few hours for natural IGF-1).

Potency: It acts as a direct IGF-1 receptor agonist and is estimated to be significantly more potent in stimulating protein and DNA synthesis in experimental settings than native IGF-1.

Proposed and Experimental Uses

Cell Culture & Research: Originally engineered for mammalian cell culture research and scientific study to promote cell growth.

Muscle Recovery & Anabolism: Explored in experimental and bodybuilding contexts for its potential to support skeletal muscle protein synthesis, satellite cell multiplication, and tissue repair.

Body Composition: Studied for shifting nutrient partitioning to support lean mass and influence glucose handling.

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