LNP delivery system excipient mPEG-DSPE-2K

Name: LNP delivery system excipient mPEG-DSPE-2K
Brand: DALIAN HANDOM CHEMICALS CO.,LTD.
Price: 140.00 USD
Availability: InStock

Price 140.00 USD ($)/ Gram

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MOQ : 1 Gram

LNP delivery system excipient mPEG-DSPE-2K Specification

Smell
No Smell

Solubility
Sparingly soluble in Chloroform and Methanol

Shelf Life
24 Months

Taste
Other

Melting Point
53 ~ 54

Storage
Freezer

Molecular Formula
C45H87NNaO11P

HS Code
3907209090

Medicine Name
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

Chemical Name
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]

CAS No
147867-65-0

Type
Other

Grade
Medicine Grade

Usage
DSPE-MPEG2000 is used as one of the LNP Delivery System Excipients for mRNA medicines or drugs.

Purity(%)
Not less than 95.0%

Appearance
White or off-white solid

Physical Form
Powder

LNP delivery system excipient mPEG-DSPE-2K Trade Information

Minimum Order Quantity
1 Gram

FOB Port
Shanghai or Beijing

Supply Ability
10000 Grams Per Month

Delivery Time
10 Days

Sample Available
Yes

Sample Policy
If order is confirmed we will reimburse the sample cost

Packaging Details
1g/bottle, 5g/bottle or according to the requirements from customers.

Main Export Market(s)
Asia, Australia, North America, Western Europe, Middle East, Africa, Eastern Europe, South America, Central America

Main Domestic Market
All India

Certifications
ISO

About LNP delivery system excipient mPEG-DSPE-2K

MPEG2000-DSPE combines the amphiphilic properties of phospholipids and the hydrophilic polymer properties of PEG. In recent years, its application in drug carriers such as long-circulating liposomes, polymer micelles, and long-circulating nanoparticles has achieved rapid development. According to the management of pharmaceutical excipients in my country, the molecular weight of polyethylene glycol in the MPEG2000-DSPE molecule is about 2000, which is suitable for the preparation of long-circulating liposomes, so that liposomes will not be captured by MPS-rich tissues immediately after intravenous injection. As a result, the circulation time in the blood is prolonged, thereby increasing the chance of entering pathological tissues.

The amount of MPEG2000-DSPE in doxorubicin liposome DOXIL accounted for 20% of the total lipid, and compared with ordinary doxorubicin liposome Mycoet, the kinetic difference was obvious. The plasma half-life of liposomal doxorubicin, DOXIL is 2.5d, while Myocet is only 0.07h.

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